Shared genetic etiology underlying Alzheimer's disease and type 2 diabetes
نویسندگان
چکیده
منابع مشابه
Shared genetic relationships underlying generalized vitiligo and autoimmune thyroid disease.
BACKGROUND Generalized vitiligo is an autoimmune disease of skin pigmentation that is associated with increased prevalence of other autoimmune diseases, particularly autoimmune thyroid disease (AITD; principally Hashimoto's disease and Graves' disease), both in vitiligo patients and their close relatives, suggesting a heritable predisposition involving, in part, shared susceptibility genes. S...
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BACKGROUND Two inflammatory disorders, type 1 diabetes and celiac disease, cosegregate in populations, suggesting a common genetic origin. Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared. METHODS We evaluated the association between type 1 diabetes and eight loci related to the risk of celiac disease by genotyping an...
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Inflammatory cytokines increase in patients with type 2 diabetes (T2D) and metabolic syndrome. This review focuses on inflammatory cytokines such as C-reactive protein (CRP), tumor necrosis factor (TNF-α), and adiponectin, a cytokine produced by adipose tissue and associated with insulin sensitivity. Despite the major role of cytokines in the development of T2D, in the case of adiponectin still...
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Genome-wide association studies (GWAS) have identified >100 independent SNPs that modulate the risk of type 2 diabetes (T2D) and related traits. However, the pathogenic mechanisms of most of these SNPs remain elusive. Here, we examined genomic, epigenomic, and transcriptomic profiles in human pancreatic islets to understand the links between genetic variation, chromatin landscape, and gene expr...
متن کاملShared genetic risk factors for type 1 diabetes and celiac disease.
Some families seem to be afflicted with more than their fair share of chronic illness — and sometimes more than one. Why does a particular disease develop in some members of a given family, whereas other members fall victim to apparently unrelated conditions? A simple model is that exposure to environmental risk factors in a genetically susceptible host leads to disease. A particular combinatio...
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ژورنال
عنوان ژورنال: Molecular Aspects of Medicine
سال: 2015
ISSN: 0098-2997
DOI: 10.1016/j.mam.2015.06.006